23 Jul Gel prepared from chitosan or chitosan derivatives by multi-crosslinking and preparation method
Abstract
The invention relates to gel prepared from chitosan or chitosan derivatives by multi-crosslinking and a preparation method. By multi-crosslinking chitosan or the chitosan derivatives, the elasticity modulus and the viscous modulus of the gel are increased and the swelling degree of the gel is reduced under the condition that the crosslinking degree of the gel is not increased. The elasticity modulus and the viscous modulus of the chitosan gel can be further increased each time one crosslinking is increased in the multi-crosslinking process, and the viscoelastic modulus of the gel can be increased by multi-crosslinking under the condition of equal crosslinking degree. The crosslinking times of the chitosan gel are selected according to characteristics of the viscoelastic modulus of different tissue parts, so that the viscoelastic modulus of the chitosan gel is matched with the related tissue, the histocompatibility of the gel in the tissue can be improved, and the use quantity of a crosslinking agent which is irritant or toxic to a human body can be reduced. The gel is applied to the field of soft tissue in tissue engineering such as tissue filling and repair, joint viscoelasticity replenishers, biological scaffolds, anti-cicatricial, anti-adhesion and biological glue and the like.
Year: 2017
Country: CN
Doc No: 107325306