23 Jul Galactosyl temperature-responsive polymer hydrogel and preparation method thereof
Abstract
The invention discloses a galactosyl-based temperature-sensitive polymer hydrogel and a preparation method thereof. The hydrogel is a Poly (NIPAAm-co-GAC) copolymerized hydrogel. The preparation method comprises three steps of: (1) synthesizing an intermediate L-NH2 with an aminogalactose group; (2) synthesizing an intermediate monomer GAC with galactosyl group and double bonds; and (3) preparing the Poly (NIPAAm-co-GAC) copolymerized hydrogel by using the NIPAAm (N-isopropylacrylamide) and the intermediate monomer GAC. The hydrogel has good temperature response and biocompatibility, and has good identification effect on hepatocytes; and can be used as a matrix material in tissue engineering for promoting cell adhension and growth in cell culture, and the cells can be automatically detached due to the temperature sensitivity of the hydrogel.
Year: 2008
Country: CN
Doc No: 101293943