23 Jul Functional modification method for cytomembrane
Abstract
The invention discloses a functional modification method for cytomembrane. The method is characterized in that hydrophobic molecules are inserted into a cytomembrane phospholipid bilayer though the hydrophobic effect of the hydrophobic molecules modified on a DNA tetrahedron so as to realize the anchoring of the tetrahedron on the surface of the cytomembrane; a DNA sequence is extended on the vertex, not modified with the hydrophobic molecules, of the DNA tetrahedron, or the extended DNA sequence is combined with other functional units to complete the functional modification of the cytomembrane. The method can not only modify probe molecules on the cytomembrane rapidly, efficiently and losslessly, but also remarkably improve the stability of probes on the cytomembrane and molecular recognition performance of the probes. In addition, based on the programmability of a DNA nanostructure, high-efficient self-assembly of multiple function modules on the cytomembrane can be realized, and a new technology is provided for the research of fields of cell and molecular biology, tissue engineering, cell-based diagnosis and treatment and the like.
Year: 2019
Country: CN
Doc No: 110172438