23 Jul Folic acid targeted antitumor medicine sustained-releasing carrier and preparation method of same
Abstract
The invention discloses a folic acid targeted antitumor medicine sustained-releasing carrier and a preparation method of same, and belongs to the field of biomedical materials. The sustained-releasingcarrier is prepared through the steps of: 1) preparing mono-dispersed micro-nano bioactive glass through a sol-gel method with combination of organic template self-assembly technology; 2) modifying the surface of the micro-nano bioactive glass by grafting amino groups via a silane coupling agent; 3) conjugating the amino groups with a gamma-carboxyl group on folic acid; and 4) supporting an antitumor medicine, methotrexate, onto the material through covalent combination. According to the invention, the folic acid is combined with a folate receptor on surface of a tumor cell membrane, and thenthe medicine carrier is transferred into a cell through the endocytosis of the cell membrane; with degradation of the bio-glass, the antitumor medicine is slowly released. The folic acid targeted antitumor medicine sustained-releasing carrier has good biocompatibility and improves efficiency that the carrier enters a tumor cell. The sustained-releasing carrier can be used in the fields of targeted therapy of tumor cells, medicine sustained releasing, bone tissue engineering, etc.
Year: 2018
Country: CN
Doc No: 107744593