23 Jul Fibroin/bacterial cellulose composite hydrogel, and preparation method and application thereof
Abstract
The invention provides a fibroin/bacterial cellulose composite hydrogel, and a preparation method and application thereof. According to the invention, bacterial cellulose hydrogel surface-modified by glycidyl trimethyl ammonium chloride, bone morphogenetic protein-2 and fibroin are used as raw materials; electrical gel technology is employed for formation of a network pore structure by the fibroin on the surface and in the internal network pore structure of the surface-modified bacterial cellulose hydrogel so as to compose a dual-network pore structure; and the morphogenetic protein-2 is adhered into the dual-network pore structure so as to form the fibroin/bacterial cellulose composite hydrogel. The preparation method is simple, highly efficient, green and environment-friendly; and the prepared composite hydrogel has high mechanical strength, high porosity, good connectivity of the interiors of pores and good biocompatibility, and is applicable as a cartilage repairing scaffold to the field of cartilage-repairing tissue engineering.
Year: 2017
Country: CN
Doc No: 106492286