23 Jul Enzyme-mediated modification of fibrin for tissue engineering
Abstract
Matrices covalently bound to bidomain peptides or proteins, produced recombinantly or synthetically, contain a transglutaminase substrate domain and a bioactive factor. The bioactive factor is preferably a growth factor, such as VEGF, growth factors from the TGF-beta superfamily, PDGF, human growth hormone, IGF, and ephrin. Particularly preferred growth factors are TGF-beta1, BMP 2; VEGF121 and PDGF AB. The matrix material is crosslinkable, and may form a gel. These compositions are useful for tissue repair and regeneration.
Year: 2002
Country: US
Doc No: 2002168718