23 Jul Drug-loading micro-needle promoted and controlled by nanogold photo-thermal effect
Abstract
The invention relates to a drug-loading micro-needle promoted and controlled by a nanogold photo-thermal effect. The drug-loading micro-needle is composed of three components including gold nanoparticles, a photosensitizer wrapped by a lipidosome and a soluble micro-needle substrate material, wherein the mass concentration ratio of the three components in the micro-needle is 1:(1-50):(1-100). By utilizing the nanogold photo-thermal effect, the photo-thermal effect is generated by stimulating nanogold mixed in the micro-needle, so that decomposition of the micro-needle is promoted; therefore, rapid and controllable release of drugs are realized; when nanogold and the drugs enter skin tissue, the skin tissue permeability can be continuously increased through the nanogold photo-thermal effect, so that the drugs can be well delivered into deep tissue. The drug-loading micro-needle disclosed by the invention is a medical application research by combining an optical technology with a micro and nano technology in the field of biomedical engineering; in particular for a micro-needle system loaded with photosensitizer drugs, in the event of monitoring the photosensitization in tissue in real time, individual photodynamic therapy based on individual differences of patients can be realized through control of drug release by nanogold.
Year: 2015
Country: CN
Doc No: 104645331