23 Jul Double-crosslinked sodium alginate hydrogel and preparation method and application thereof
Abstract
The invention belongs to the technical field of biomedical materials and discloses double-crosslinked sodium alginate hydrogel and a preparation method and application thereof. The preparation method includes: dissolving sodium alginate into deionized water, adding activating agents to activate, adding furfurylamine to react for 12-36 hours, and subjecting a reaction product to dialysis and freeze drying so as to obtain furan-modified sodium alginate; dissolving the furan-modified sodium alginate into the deionized water, adding maleimide-terminated polyvinyl alcohol, stirring sufficiently to dissolve, performing ultrasonic treatment, injecting into a mould, and crosslinking at 37-60 DEG C so as to obtain gel; soaking the gel into a calcium chloride solution for 12-48 hours for physical crosslinking so as to obtain the double-crosslinked sodium alginate hydrogel. By the aid of a double-crosslinking method consisting of click chemistry crosslinking and ionic crosslinking, the obtained double-crosslinked sodium alginate hydrogel has excellent mechanical and anti-swelling properties and can be applied to scaffolds for tissue engineering.
Year: 2016
Country: CN
Doc No: 105713106