23 Jul Difunctional integrated bone-cartilage composite tissue engineering scaffold for clinic treatment of osteosarcoma
Abstract
The invention relates to a difunctional integrated bone-cartilage composite tissue engineering scaffold for clinic treatment of osteosarcoma. Firstly, polylactic acid/hydroxyapatite hard bone and calcium carbonate glucolactone/sodium alginate (CaCO3-GDL-SA) cartilage scaffolds are prepared by solvent casting-particle leaching and compound ion crosslinking network technologies respectively. The integrated bone-cartilage composite scaffold has bionic gradient change in physical and biological performance, is expected to fill various defects in irregular shapes and can effectively promote simultaneous generation of bone-cartilage tissue defects after osteosarcoma excision. CR780-PEG5K nanoparticles uniformly dispersed in the CaCO3-GDL-SA cartilage hydorgel scaffold can remove osteosarcoma cells under near infrared illumination on the basis of good photothermal effect. The difunctional integrated bone-cartilage composite scaffold provides theoretical basis and technical support for existing clinical tretament schemes of the osteosarcoma.
Year: 2019
Country: CN
Doc No: 110420356