23 Jul DEVICE FOR TISSUE ENGINEERING BONE
Abstract
A device for bone tissue engineering is described which comprises a scaffold material consisting of a bioactive, osteoconductive and bone-bonding segmented thermoplastic copolymer and cultured osteogenic or osteoprogenitor cells, especially bone cells. The copolymer consists essentially of a multiplicity of recurring long-chain ester units and short-chain ester units, the long-chain ester units comprising from 35 to 80% by weight of the copolyester and being represented by the formula -OLP-CO- or -OLO-CO-R-CO-and the short-chain ester units being represented by the formula -OEO-CO-R-CO- and/or -O-Q-CO-wherein L is a divalent group remaining after removal of terminal hydroxyl groups from a poly(oxyalkylene) glycol with an average molecular weight of between 300 and 3000; R is a divalent group remaining after removal of carboxyl groups from a dicarboxylic acid having a molecular weight of less than 300; Q is an alkylene group having 1-6 carbon atoms and/or a cyclohexylene of phenylene group; and E is an alkylene group having 2-6 carbon atoms.
Year: 1999
Country: CA
Doc No: 2243248