23 Jul Degradable photosensitive phosphate copolymers
Abstract
The invention provides degradable photosensitive phosphate copolymers, belonging to the technical field of functional polymer materials. According to the invention, ethyl dichlorophosphate (EDP), caprolactone (CL) and lactide (LA) are used as monomers, bishydroxyl-terminated polycaprolactone (PCL) and polylactide (PLA) are used as raw materials, and melt-phase polycondensation are carried out to prepare a series of phosphate copolymers PPE-PCL and PPE-PLA; then through further chemical modification, a cinnamoyl group is introduced to the tail end of a polymer chain so as to prepare the photosensitive phosphate copolymers PPE-PCL-C and PPE-PLA-C. A micelle prepared by self-assembling of the phosphate polymers in a mixed medium has certain degradability and photosensitivity. The polymers prepared in the invention have good biodegradability and biocompatibility and can be applied to biomedical fields like drug delivery and tissue engineering.
Year: 2016
Country: CN
Doc No: 105384941