23 Jul Degradable phosphorylated material, preparation method thereof, and applications of degradable phosphorylated material in osteogenesis
Abstract
The invention relates to a degradable phosphorylated material, a preparation method thereof, and applications of the degradable phosphorylated material in osteogenesis. The degradable phosphorylated material is poly(glycerol sebacate)phosphate PGS-P with phosphorus content larger than 0% and lower than 9.14%. The preparation method comprises following steps: (1) synthesis of PGS, and (2) synthesis of PGS-P. The degradable phosphorylated material can be used for preparation of tissue engineering scaffolds. Synthesis of the degradable phosphorylated material is simple; structure of the degradable phosphorylated material is controllable; phosphorylation degree of the degradable phosphorylated material can be adjusted effectively; the degradable phosphorylated material possesses excellent osteogenic activity, and the osteogenic activity can be adjusted via adjusting of phosphorylation degree; a novel material is provided for biomedicine application such as osteanagenesis, and design thought of the degradable phosphorylated material can be applied to design of other similar phosphorylated materials and osteogenesis active materials; the preparation method is simple; cost is low; and application prospect is promising.
Year: 2015
Country: CN
Doc No: 104910360