23 Jul Degradable gel microspheres interposed in bronchus and application thereof
Abstract
The invention relates to degradable gel microspheres interposed in a bronchus and application thereof. The degradable gel microspheres comprise hyaluronic acid-calcium alginate gel microspheres and medicament-loaded chitosan-calcium alginate gel microspheres, wherein the hyaluronic acid-calcium alginate gel microspheres and the medicament-loaded chitosan-calcium alginate gel microspheres are mixed together uniformly according to proportion, and the volume ratio is 2:1-9. The degradable gel microspheres can be used for preparing sustained-release and controlled-release medicaments for treatinglung cancer, lung tumor, tuberculosis, pneumonia and bronchitis and a tissue engineering scaffold material. The degradable gel microspheres interposed in the bronchus do not block up a lung bronchus and also do not initiate ischemic necrosis of surrounding tissues of the bronchus, so the degradable gel microspheres can be used as the tissue engineering scaffold material and a medicament sustained-release scaffold. Two types of microspheres with different functions have complementary advantages, overcome the technical difficulties of microsphere blockage and pulmonary ventilation in the bronchus, and can significantly reduce toxic or side effect of medicaments and improve therapeutic indexes of the medicaments.
Year: 2010
Country: CN
Doc No: 101912366