23 Jul Degradable controllable bone tissue engineering scaffold based on 3D printing and preparation method thereof
Abstract
The invention relates to the technical field of biomedical materials, which relates to a 3D printing material, in particular to a 3D printing multilayer micro-nano structure controllable porous bioactive ceramic material. The bioactive ceramic scaffold of the invention is a model with a certain macropore through parametric modeling design, and 3D printing technology is used to shape a certain ratio of calcium phosphate raw materials into the designed model. The porous calcium phosphate scaffolds were fabricated by sintering the calcium phosphate scaffolds, and then the micro-nano-structure ofthe scaffolds was changed by solution recrystallization. In this invention, by adjusting the ratio of hydroxyapatite (HA) to tricalcium phosphate (TCP) in the raw material, the primary macropore structure of the scaffold was designed, and the secondary micro-nano morphology and structure of the scaffold were controlled by controlling the environmental parameters of the solution recrystallization reaction medium, such as temperature, time, pH value of the medium and so on. The scaffolds for bone tissue engineering could be customized according to different patients.
Year: 2019
Country: CN
Doc No: 109260525