23 Jul Decellularized eyelid board and preparation method thereof
Abstract
The invention discloses a decellularized eyelid board and a preparation method thereof. The accellular eyelid board adopts an eyelid board of a heterogeneous animal or an allogeneic eyelid board as a raw material which is subjected to decellularization treatment to obtain the decellularized eyelid board. The accellular eyelid comprises eyelid board bodies on two sides. A plurality of collagen fibreboard layers which are respectively arranged in the crossing directions are arranged between the eyelid board bodies. A plurality of meibomian gland tubes are arranged between the collagen fibreboard layers. Spaces formed after cells are removed are also formed between the collagen fibreboard layers. The decellularized eyelid board can be used for repairing defects and reestablishment of eyelid tissues, shaping the eyelid tissues and treating eyelid diseases, and can be used as a carrier for building a tissue-engineering biological eyelid board. The decellularized eyelid board can exist in a long term after being transplanted and has the functions of meibomian glands of a receptor. Nerves, blood vessels and lymph vessels can grow into the decellularized eyelid board, and cells of the receptor can be attached to and grow on the surface of the decellularized eyelid board in a long term. The decellularized eyelid board has the advantages of being low in immunogenicity and good in histocompatibility, and having wide application prospect.
Year: 2013
Country: CN
Doc No: 103127549