23 Jul Curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane and preparation method thereof
Abstract
The invention discloses a curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane and a preparation method thereof. The preparation method is characterized by comprising the steps that firstly, dichloromethane and ethyl alcohol which have the certain volume ratio are mixed to be prepared into an electrostatic spinning solvent; secondly, curcumin, PCL and PVP which have the certain mass proportion are mixed to be added into the electrostatic spinning solvent and stirred at room temperature until the mixture is transparent, spinning mother liquid with the concentration of 6%-12% is prepared, the spinning mother liquid is injected into electrostatic spinning equipment to be spun, and then a curcumin-loaded PCL-PVP composite micro-nano fiber membrane is obtained; thirdly, the composite membrane is placed in an ultrasonic generator to be subjected to intermittent ultrasonic treatment; lastly, the composite membrane is steeped into an I type collagen solution and naturally aired, and then the curcumin-loaded collagen-PCL-PVP composite micro-nano fiber membrane is prepared. The material has the good biocompatibility and biodegradability, can promote cell growth, proliferation and adhesion, has the effects of resisting inflammations and oxidization, promoting wound healing and the like and can be used as a tissue engineering scaffold, high-grade dressings, a hemostatic material and the like.
Year: 2016
Country: CN
Doc No: 106049026