23 Jul COMPOSITION FOR ADHESION OR PROLIFERATION OF DENTAL PULP CELLS COMPRISING RECOMBINANT DENTIN PHOSPHOPROTEIN
Abstract
The present invention relates to a composition comprising dentin phosphoprotein as an active ingredient to promote the adhesion or proliferation of dental pulp cells; and to a method to induce the adhesion or proliferation of dental pulp cells, which comprises a step of treating dental pulp cells with the dentin phosphoprotein. It has been verified that the proliferation of dental pulp cells is promoted, cell-adhesion ability increased and the differentiation of the dental pulp cells into odontoblasts can be promoted using recombinant human dentin phosphoprotein capable of being mass-produced by an expression vector. Therefore, the recombinant human dentin phosphoprotein in the present invention can widely be used to promote the proliferation and adhesion of dental pulp cells in the field of developing a tissue-engineering material related to the recovery and regeneration of teeth and osseous tissue, a dental therapeutic agent for osteanagenesis, and a dental medicine.
Year: 2014
Country: KR
Doc No: 20140095295