23 Jul Composite biology bracket material for repairing bone defects
Abstract
The invention discloses a composite biology bracket material for repairing bone defects, and belongs to the technical field of bone tissue engineering. Reorganized TG2 gland viruses are transfected toEMSCs having multi-direction differentiation potency, in vitro assessment is performed on influence of TG2-EMSCs on osteogenesis of a fibrin bracket, and a bioactivity bracket containing TG2-EMSCs istransplanted into SD rats with skull defects, and the bone defect capacity is detected. Results prove that the fibrin bracket containing TG2-EMSCs is used for performing transplanting treatment on the skull defects, 55% of the damaged regions can be healed within two weeks, and the fibrin bracket containing natural EMSCs prove that 17% of the damaged regions are healed within the same time. The biology bracket is high and stable in biocompatibility, low in cost and simple and convenient to operate, and therefore, the fibrin bracket containing TG2-EMSCs has important clinical application valueto repair of the skull defects.
Year: 2019
Country: CN
Doc No: 109847098