23 Jul Complete biological artificial intervertebral disk and preparation method thereof
Abstract
The invention provides a tissue engineering biological stent system for regenerating complete intervertebral disks. The system comprises a nucleus pulposus stent, an annulus fibrosus stent, end platestents and a peripheral elastic support ring; the nucleus pulposus stent is located at the center of the whole biological stent system, the annulus fibrosus stent is circumferentially arranged aroundthe nucleus nucleus stent, the end plate stents are arranged in the axial direction of the annulus fibrosus stent and cover the two ends of the annulus fibrosus stent, and the peripheral elastic support ring circumferentially wraps the annulus fibrosus stent and the end plate stents; the nucleus pulposus stent is made of biodegradable hydrogel; the annulus fibrosus stent is of a multi-layer structure formed by coaxially winding biodegradable elastic membranes; the end plate stents are made of a biodegradable porous material; the peripheral elastic support ring is a biodegradable non-porous elastic ring. The invention further provides a complete biological artificial intervertebral disk regenerated based on the biological stent system and a preparation method thereof. The biological artificial intervertebral disk has a complete mammalian intervertebral disk structure and has biomechanical properties close to those of a natural intervertebral disk.
Year: 2018
Country: CN
Doc No: 108498870