23 Jul Collagen/polyvinyl alcohol composite microspheres as well as preparation method and application thereof
Abstract
The invention provides collagen/polyvinyl alcohol composite microspheres as well as a preparation method and application thereof, belonging to the field of high polymer composite materials. The microsphere diameter of the collagen/polyvinyl alcohol composite microspheres is 100-1000nm, and the microspheres are connected into the shape of a string of beads by using collagen/polyvinyl alcohol composite nano-fibers, or are connected into the shape of a net by taking the microspheres as nodes and using the composite nano-fibers. The preparation method of the collagen/polyvinyl alcohol composite microspheres comprises the following steps of: (1) dissolving collagen into an acetic acid aqueous solution to prepare a collagen solution of which the concentration is 7-25g/L; and (2) uniformly mixing the collagen solution with a polyvinyl alcohol aqueous solution of which the concentration is 6-12wt% in a weight ratio of (1-9):1, and performing electrostatic spinning, wherein the distance between a spinning needle head and a receiving plate is 8-30cm, the voltage is 8-30kV, the spinning flow rate is 0.1-10mL/h, and the spinning temperature is 25-35 DEG C. The collagen/polyvinyl alcohol composite microspheres provided by the invention can be used as a scaffold material for biological tissue engineering or used as a medicament slow-release material.
Year: 2013
Country: CN
Doc No: 103276472