23 Jul Collagen-chitosan scaffold containing nano-silver
Abstract
The invention provides a collagen-chitosan scaffold containing nano-silver. The collagen-chitosan scaffold containing nano-silver is prepared through the steps that nano-silver and a collagen-chitosan solution are mixed uniformly and then a mixture is subjected to one-step freeze-drying and cross-linking, wherein the concentration range of the nano-silver is 10mu g/ml-50mu g/ml, and the particle size of nano-silver particles is 10-30 nm. The scaffold not only has functions of resisting bacteria, promoting wound surface healing and the like, but also provides a reasonable nano-silver sustained-release system for a wound surface, long-term effective drug sustained release is provided for the wound surface, and the drug concentration of the wound surface keeps equalized, effective and non-excessive. The collagen-chitosan scaffold is a novel medical dressing, prevents and resists infection and inflammation in a wound surface repair process, and promotes better vascularization of local tissue; according to the novel dressing, not only is the clinical application range of nano-silver broadened, but also the mechanism that the nano-silver promotes the wound surface healing can be further illustrated, and one novel promoting means is provided for effective usage of tissue engineering products.
Year: 2016
Country: CN
Doc No: 105749322