23 Jul Collagen-based interpenetrating polymer network tissue engineering cornea substitute and preparation method thereof
Abstract
The invention relates to a collagen-based interpenetrating polymer network tissue engineering cornea substitute and a preparation method thereof. The cornea substitute is mainly prepared by taking collagen and 3-(methacrylamide)propyl-dimethyl(3-sulfopropyl)amide (MPDSAH) as raw materials and water as a solvent which react in the presence of a crosslinking agent and a photo initiator and are subjected to a pouring film forming processing process, and the composition and mixture ratio comprise that: the molar ratio range of carbodiimide to collagen amino group (calculated by the number of amino groups on collagen molecules) is 0.3-5.0:1; the molar ratio of the carbodiimide to N-hydroxyl succinimide is 1:1; the molar ratio of N,N’-bi(acryl)acystamine and the 3-(methacrylamide)propyl-dimethyl(3-sulfopropyl)amide is 0.01-0.10:1; and the molar ratio of the photo initiator Irgacure2959 to the 3-(methacrylamide)propyl-dimethyl(3-sulfopropyl)amide is 0.01-0.10:1. The cornea substitute has good biocompatibility, mechanical property, optical property, thermal property and controllable biodegradability, the preparation method is simple, and the product is easy for long-term storage and long-distance transportation.
Year: 2009
Country: CN
Doc No: 101543642