23 Jul CO-CONTINUOUS HYBRID STRUCTURE FOR THE REGENERATION OF BONE DEFECTS
Abstract
The invention relates to a method for obtaining a scaffold consisting of a porous PCL matrix and a hydroxyapatite coating, comprising the following steps: (i) preparing a homogeneous PCL solution in a mixture of two solvents, namely a PCL solvent and a PCL nonsolvent (ii) filling a mould with the homogeneous solution (iii) cooling the homogeneous solution to a temperature lower than the temperature at which the separation of the two liquid phases occurs (iv) isothermal treatment (v) solidifying both phases, reducing the temperature (vi) extracting the PCL solvent and the PCL nonsolvent, together with a third solvent and (vii) depositing biomimetic HAp. The structure is suitable for use in tissue engineering.
Year: 2009
Country: ES
Doc No: 2330823