23 Jul Chitosan semi-fluid slow release gel and application
Abstract
The invention discloses a chitosan semi-fluid slow release gel. The chitosan semi-fluid slow release gel comprises an ingredient I and an ingredient II, wherein the ingredient I is obtained by dissolving 0.5020g/ml of prepared chitosan solution at the temperature of 4 DEG C with normal saline or distilled water as a solvent, and the ingredient II is obtained by dissolving 0.251g/ml of prepared hyaluronic acid chitosan solution at the temperature of 4 DEG C with mixed liquid formed by saturated sodium bicarbonate water solution and distilled water at the volume ratio of 1:1 as a solvent. The chitosan semi-fluid slow release gel is prepared by the steps that the ingredient I and the ingredient II are proportionally mixed at the normal temperature before usage to form a mixture in an injectable semi-fluid state, the injected position gradually solidifies and is finally cured when the temperature rises in a range from 26 DEG C to 40 DEG C, and slow drug release can be controlled. A semi-fluid gel preparation prepared by the gel can serve as a drug carrier and a scaffold for tissue engineering. The chitosan semi-fluid slow release gel is biodegradable and good in biocompatibility.
Year: 2014
Country: CN
Doc No: 104208711