23 Jul Chitosan-based gradient bionic composite stent material and construction method thereof
Abstract
The invention discloses a chitosan-based gradient bionic composite stent material and a construction method thereof, and belongs to the field of tissue engineering materials. Isopyknic Cs/GP/Gel solution and acetic acid solution are added into a vessel A and a vessel B respectively which are horizontally communicated through a communicating pipe, the Cs/GP/Gel solution continuously flows into a stent mold, and the acetic acid solution continuously flows into the vessel B; when the solutions in the two vessels continuously flow into the stent mold, a stent pre-product is taken out after pre-frozen treatment, and a Cs/GP/Gel gradient composite stent is obtained by preparation; during the preparation of the Cs/GP/Gel gradient composite stent, when residual liquor in the vessel B is one fourthto one fifth, a Cs/GP/Gel/nHAp solution is added into the vessel B, and other steps are the same as those of the Cs/GP/Gel gradient composite stent. The aperture of the gradient composite stent prepared with the method shows obvious gradient progressivity, and pores are mutually communicated, so that cartilage calcification layer and cartilage layer simulated by nHAp have a good connection effect, and are applicable to the field of cartilage tissue engineering.
Year: 2018
Country: CN
Doc No: 107638590