23 Jul Chitin fiber reinforced collagen base bone tissue engineering scaffold with compounded human mesenchymal stem cells and preparation method
Abstract
The invention discloses a bone tissue engineering scaffold which compounds bone-like tissue engineering materials with human mesenchymal stem cells and a preparation method of the bone tissue engineering scaffold, and belongs to the technical field of tissue engineering. The bone tissue engineering material is prepared by compounding mineralization collagen (MC), polylactic acid (PLA) and natural chitin woven high-strength fiber (CHF); because of the adding of the MC, the material is good in mechanics integration, and the components of the material are close to natural bones; due to the adding of the PLA, the material is good in molding property; by adopting the CHF, the material is enhanced, and the acid degradation product of the PLA is neutralized by the degradation product; and the bone tissue engineering material can be degraded and has a three-dimensional porous structure. By adopting the scaffold formed by compounding the bone tissue engineering material with the human mesenchymal stem cells, people go through goat tibia bone defect with the bone spaces of 25mm after eight weeks, the bone defect is completely recovered after the implantation of the scaffold, and the recovery effect and the self-bone have no obvious difference; and therefore, the bone tissue engineering scaffold is hopefully applied to clinic.
Year: 2013
Country: CN
Doc No: 102989041