23 Jul Cell matrix modified tissue engineering nerve graft for repairing peripheral nerve injury and preparation method thereof
Abstract
The invention discloses a tissue engineering nerve graft for repairing peripheral nerve defect and a preparation method thereof, wherein the tissue engineering nerve graft is formed by constructing nerve conduits and cell matrixes. The preparation method comprises the steps of constructing the tissue engineering nerve graft containing sustentacular cells and a cell matrix modified tissue engineering nerve graft. The advantages of the cell matrix modified tissue engineering nerve graft disclosed by the invention are obvious; the cell matrixes on the nerve conduits and a support are obtained by decellularizing after forming cultured cells; the cell matrixes are completely natural cell matrixes, are more beneficial to adhering cells, and have a certain guide action on the directionality of axonal regeneration, therefore, nerve regeneration process is beneficial to being enhanced; simultaneously, the transplantation immunogenicity of allogeneic cells can be reduced or avoided after decellularizing; an environment beneficial to regeneration axon growth is established; ideal goals of rapid growth of nerves and function recovery are achieved; and a feasible proposal is provided for clinic treatment.
Year: 2013
Country: CN
Doc No: 103041450