23 Jul Cartilage tissue engineering scaffold and preparation method thereof
Abstract
The invention discloses a cartilage tissue engineering scaffold and a preparation method thereof and belongs to the field of cartilage repair. The cartilage tissue engineering scaffold comprises a chitosan hydrogel outer skeleton and at least one decalcified cortical bone matrix microsphere coated in the chitosan hydrogel outer skeleton and with bone marrow mesenchymal stem cell affinity peptide modified on the surface, wherein diameter of each decalcified cortical bone matrix microsphere is 500-800 micrometers. The cartilage tissue engineering scaffold has high rheological property, easiness in plasticizing, biomechanical strength and performance of specifically gathering bone marrow mesenchymal stem cells, thereby being suitable for cartilage defect areas different in shape, lasting in effect and capable of acquiring more differentiated cartilage cells, has high cartilage tissue repair ability and is convenient for large-scale popularization and application.
Year: 2016
Country: CN
Doc No: 105268028