23 Jul Carbonate polymer with disulfur five-membered ring functional group on side chain and application thereof
Abstract
The invention discloses a carbonate polymer with a disulfur five-membered ring functional group on a side chain and an application thereof. The polymer is obtained by active ring opening polymerization from a cyclic carbonate monomer containing the disulfur five-membered ring functional group; the polymer is controllable in molecular weight, narrower in weight molecular distribution and free from protecting and deprotecting process. The polymer obtained by active ring opening polymerization of the cyclic carbonate monomer has biodegradability and can be used for controlling a drug release system; a reduction-sensitive reversible crosslinking nano medicine carrier targeting tumor supports long circulation in vivo but is highly enriched in tumor cells and is quickly crosslinked to release medicine in cells so as to efficiently kill the tumor cells with specificity. Meanwhile, the carbonate polymer has an application prospect in aspects such as tissue engineering scaffolds and biochip coatings and the like.
Year: 2014
Country: CN
Doc No: 104031248