23 Jul Bone tissue engineering scaffold
Abstract
The utility model discloses a bone tissue engineering support which comprises a hollow latticed support and porous zinc-based metal balls filled in the hollow latticed support, and the porous zinc-based metal balls are solid balls with hole grooves in the surfaces or fluffy balls formed by rolling metal wires. A supporting column can also be arranged in the bracket so as to provide better mechanical properties; beta-TCP particles may also be filled to enrich bone marrow mesenchymal stem cells. According to the utility model, the grid bracket made of titanium or zinc-based metal and the internal support columns are combined; the bone tissue engineering scaffold with excellent mechanical property is prepared; wherein the porous zinc-based metal balls can promote osteogenic differentiation and inhibit osteoclast differentiation, promote regeneration and ingrowth of bone tissue while providing support, and then are gradually replaced by the bone tissue in the degradation process, and the beta-TCP particles can enrich mesenchymal stem cells and promote bone repair. The device can be applied to large-section bone defect of a bearing part, bone tissue regeneration is promoted on the basisof achieving mechanical support, and the curative effect of repairing the large-section bone defect is achieved.
Year: 2020
Country: CN
Doc No: 210096010