23 Jul Bone tissue engineering scaffold material and preparation method thereof
Abstract
The invention discloses a bone tissue engineering scaffold material and a preparation method thereof. The preparation method for the bone tissue engineering scaffold material comprises the steps that firstly, fibroin / hydroxyapatite powders are synthesized according to a bionic principle, the fibroin/ hydroxyapatite powders are dissolved in sericin solution, then the sericin solution (containing the fibroin/ hydroxyapatite powders), chitosan solution and sodium glycerophosphate solution are mixed, the mixed solution is turned into hydrogel by controlling the temperature, the hydrogel is dried through prefreezing, unfreezing, refreezing and final freezing, and the bone tissue engineering scaffold material is obtained. The bone tissue engineering scaffold material has the advantages that the mechanical property is good, the biocompatibility is good, the degradability and formability matching with osteocyte growing feature are good, and the osteocyte can be induced to grow into the material; the physiological process of the ingrowth of the osteocyte is accelerated, the performance to promote the growth of the osteocyte is achieved, the recovery time of a patient can be shortened, the clinic treatment process is accelerated, and the pain of the patient is decreased. The preparation method has the advantages of being mild in reaction condition, simple in technique, low in cost and suitable for amplifying production.
Year: 2015
Country: CN
Doc No: 104984393