23 Jul BMP loaded silk fibroin/collagen scaffold material and preparation method thereof
Abstract
The invention discloses a BMP loaded silk fibroin/collagen scaffold material. The material is prepared with collagen, BMP, silk fibroin and PLGA as raw materials; a preparation method comprises the steps of preparation of a loose-layer silk fibroin/collagen membrane and a dense-layer silk fibroin/collagen membrane, preparation of BMP loaded PLGA microspheres, composite of the silk fibroin/collagen membranes and the microspheres and the like. A scaffold is a tissue engineering scaffold having no toxic or side effect on bodies and having good biocompatibility and tissue repair capacity. Based on combination of respective advantages of good biological compatibility, biological degradation and the like of two different natural biological macromolecules of silk fibroin and collagen, the BMP is introduced to the scaffold, a directional controlled-release slow-release technology is adopted, the BMP is allowed to be released persistently, the problems of relatively short in-vivo half-life period of the BMP, growth factor directional introduction local defect repairing and the like are solved effectively, and full playing of functions are prolonged.
Year: 2015
Country: CN
Doc No: 104707180