23 Jul BMP composition for synergistic induction of ossification differentiation, and application thereof
Abstract
The invention discloses a BMP composition for synergistic induction of ossification differentiation. The BMP composition comprises of a BMP 9 and a MBP 2, 4, 6 or 7, and has a stronger induction effect on ossification differentiation than a single BMP. The invention also discloses a BMP gene recombinant virus composition and a BMP double-gene coexpression recombinant virus, which express the BMP composition for synergistic induction of ossification differentiation in eukaryotic cells, and can introduce the BMP 9 gene and the BMP2, 4, 6 or 7 gene into target cells and enable high efficient and stabilized expression, without in vitro translation and BMP separation and purification, so as to simplify BMP preparation process and reduce costs. The BMP composition, BMP gene recombinant virus composition and the BMP double-gene coexpression recombinant virus of the present invention can be applied to preparation of tissue engineering artificial bones and medicaments for treating bone defect, delayed unions of bones, nonunion of fractures and spinal diseases.
Year: 2011
Country: CN
Doc No: 102205112