23 Jul Block-shaped scaffold for tissue engineering and production method thereof
Abstract
To provide a block-shaped supporting body for a cell technology having a porous structure and comprising an organism absorbency high polymer material, and this supporting body has excellent shape stability and low volume change even when dipping it in water as compared with a conventional sponge-shaped supporting body. In the production method, a high polymer material containing a particle-shaped material and having the small hole structure where the hole diameter is 5 to 50 µm is produced by the steps approximate-uniformly mixing the particle-shaped material having a particle diameter of 100 to 2000 µm with a solution, where the organism absorbency high polymer is dissolved with an organic solvent and the particle-shaped material cannot be dissolved with the organic solvent, freezing it, and drying it to remove the organic solvent. Then, a granular porous material having a particle diameter of 100 to 3000 µm is produced by the steps pulverizing the produced high polymer material, and dissolving the particle-shaped material with the liquid to be removed, where the organism absorbency high polymer is not dissolved with the liquid. Then, the block-shaped supporting body for the cell technology is produced by the steps taking the produced granular porous material into a mold, and pressing and heating it, where the supporting body has ununiform and continuous holes occupied 20 to 80% in a cross-section area in a three-dimensional network structure having a small hole structure being a hole diameter of 5 to 50 µm, elastic modulus being 1 to 25MPa, and volume change being 95 to 105% when dipping it in water for 24 hours.
Year: 2006
Country: EP
Doc No: 1649876