23 Jul Black phosphorus and gelatin based composite hydrogel and application thereof to bone tissue engineering
Abstract
The invention discloses a black phosphorus and gelatin based composite hydrogel and an application of the black phosphorus and gelatin based composite hydrogel to bone tissue engineering. The composite hydrogel comprises black phosphorus and gelatin modified by double bonds, wherein the total content of the gelatin modified by double bonds is 5%-99.9%. The biocompatibility of the composite hydrogel is good, the safety is high, the composite hydrogel has excellent mechanical properties and biological performance at the same time, supports the growth and osteogenic differentiation of the cell, and has obvious effects on promoting the generation of new bones and repairing bone defects; a hydrogel matrix having the appropriate performance is specifically constructed by chemically modifying thegelatin, meanwhile, the mineralization speed of the hydrogel is controlled by using the characteristic of the black phosphorus oxidizing in the coexistence of light, oxygen and water and the induction effect of the black phosphorus on the calcium element through the photocontrol, so that the process of repairing the bone is effectively regulated and controlled. The safety of the product is good,the performance is reliable, the operation is convenient, the repeatability is good, and the composite hydrogel is easy to industrialize.
Year: 2018
Country: CN
Doc No: 108653809