23 Jul Biphysic tissue engineering joint scaffold as well as preparation method and application thereof
Abstract
The invention relates to a biphysic tissue engineering joint scaffold as well as a preparation method and an application thereof. The biphysic tissue engineering joint scaffold consists of a phrenology scaffold and a cartilage scaffold, wherein the cartilage scaffold is a PGA/PLA scaffold; the phrenology scaffold is a PCL/HA scaffold. The invention also provides a biphysic cell-tissue engineering joint scaffold constructor as well as a preparation method and an application thereof. The biphysic tissue engineering joint scaffold as well as the preparation method and the application thereof have the advantages that the biphysic tissue engineering joint scaffold is manufactured by utilizing a CAD/CAM technology, the external form and interior structure are accurate and controllable, the phrenology and the cartilage are matched with each other, the biphysic cell-tissue engineering joint scaffold constructor is formed by compositing seed cells by utilizing a tissue engineering technology, the tissue engineering joint can be regenerated in vivo and has the biological and mechanical biomechanical characteristics of the normal joint, an interface of a regenerated bones and the cartilage is well integrated, and the possibility is provided for performing biological reconstruction through the tissue engineering joint instead of the existing artificial joint.
Year: 2013
Country: CN
Doc No: 103285429