23 Jul Bionic glycosylated mineralized collagen/ glycosylated chitosan/PLGA composite bone tissue engineering bracket and preparation method thereof
Abstract
The invention relates to a bionic glycosylated mineralized collagen/ glycosylated chitosan/PLGA composite bone tissue engineering bracket and a preparation method thereof. Glycosylated mineralized collagen, glycosylated chitosan and PLGA are used as raw materials for preparing a porous composite bone tissue engineering bracket material, the composition proportion of the raw materials is adjusted,and the defects that a homogenous material is poor in moldability, low in mechanical strength and weak in cell adsorption properties, are overcome. The PLGA has favorable biocompatibility, and is freefrom toxin, and favorable in moldability. A thermally induced phase separation method is used for combining the glycosylated mineralized collagen with the glycosylated chitosan and the PLGA to prepare a three-dimensional hole network structure. The bionic glycosylated mineralized collagen/ glycosylated chitosan/PLGA composite bone tissue engineering bracket has nanostructures similar to natural bone, adhesion, proliferation and polarization of cells on the surface of a bracket material are facilitated, certain roughness and porosity factors are also favorable for growth in of newborn bone tissues on implant surfaces, and the osseointegration processes at implant /host tissue interfaces can be promoted.
Year: 2019
Country: CN
Doc No: 110038167