23 Jul Bionic eyelid scaffold having double-layer composite structure and construction method thereof
Abstract
The invention discloses a bionic eyelid scaffold having a double-layer composite structure and a construction method thereof. The bionic eyelid scaffold is mainly formed by compounding of two layers of different bionic eyelid tissue materials; a bottom layer is a porous degradable elastic polyester skeleton, and a surface layer is a natural biological material, that is a sponge; and porous degradable elastic polyester is taken as a raw material, an eyelid skeleton material having a communicating pore is prepared by using a gelatin template method, and the natural biological material is composited to the eyelid skeleton material, thus obtaining the bionic eyelid scaffold having the double-layer composite structure in tissue engineering. The elastic polyester/natural biological material composite scaffold prepared by the construction method of the invention has a matched mechanical strength and maintains an eyelid form, and simultaneously has a good biocompatibility and can promote growth and functional maintenance of fibrocytes and conjunctival cells; and the preparation method is simple, and the repeatability is good.
Year: 2020
Country: CN
Doc No: 110801535