23 Jul Biomimetic injectable adhesive hydrogel, preparation method thereof, and application thereof to biological aspect
Abstract
The invention relates to biomimetic injectable adhesive hydrogel, a preparation method thereof, and application thereof to the biological aspect, and belongs to the technical field of macromolecular materials. Firstly, natural macromolecular hyaluronic acid is modified by dopamine and the product still has high water solubility; then horse radish peroxidase and hydrogen peroxide are added, the pH is adjusted to be alkalescent, mixing is conducted uniformly through oscillation, the process of changing from sol to gel is generated, the color is changed from colorless to brown, and the adhesive property is given to the hydrogel. In addition, the original biocompatibility is high, the characteristics such as non-toxicity and degradability are retained, the performance conservation is further proved via cytotoxicity test and in-vitro degradation test, and with reference to the characteristics, the biomimetic injectable adhesive hydrogel has the potential to be a novel biological material showing capabilities in the field of biomedicine such as cell and tissue engineering.
Year: 2017
Country: CN
Doc No: 107312193