23 Jul BIOMATERIAL DEVICES AND TOPICAL COMPOSITIONS FOR GUIDED TISSUE REGENERATION
Abstract
Devices for guided tissue regeneration (GTR) comprise a matrix of chitosan and mutable collagenous tissue (MCT), wherein the chitosan is electrostatically bonded to the MCT to form an MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks, and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. The MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also have cosmeceutical applications for treating scars, as well as skin discoloration and various pigmentation issues, including melasma/chloasma.
Year: 2020
Country: KR
Doc No: 20200029362