23 Jul BIOMATERIAL COMPRISING OSTEOSTATIN FOR OSSEOUS REGENERATION AND TISSUE ENGINEERING
Abstract
The invention relates to bioactive bioceramics for the local and controlled release of the pentapeptide formed by the sequence of amino acids 107 to 111 (TRSAW) of the protein related to parathormone, the peptide known as osteostatin, and to the methods used to bind the pentapeptide to the bioceramic by covalent bonding or by adsorption. The immobilisation of PTHrP (107-111) in bioactive bioceramics enables the controlled release of said peptide and/or its local exposition, providing the bioactive-PTHrP bioceramic systems (107-111) with an osteoinductive and osteointegration capacity.
Year: 2012
Country: WO
Doc No: 2012025651