23 Jul Biological sponge based on acellular small intestinal submucosa and preparation method thereof
Abstract
The invention discloses a biological sponge based on the acellular small intestinal submucosa and a preparation method thereof. The preparation method comprises the steps of preparing the acellular porcine small intestinal submucosa, pepsin enzymatic hydrolysis, washing, lyophilization, pulverization and cross-linking. According to the preparation method, the porcine small intestinal submucosa istaken as a source; after the decellularization treatment, the immunological rejection is extremely small. At the same time, the cross-linking treatment is carried out by using a non-toxic cross-linking agent to ensure the biosafety of the obtained product. The product can be used not only for wound repair, but also as an excellent tissue engineering skin scaffold material. The product is sufficient in source, safe and reliable, cheap and easy to obtain. The composition and structure are similar to the humans. No ethical problems exist, and scale industrial preparation can be facilitated.
Year: 2019
Country: CN
Doc No: 110051884