23 Jul Biological machine using self-folding of multi-layered hydrogel and preparing method thereof
Abstract
The present invention relates to a biological robot using self-folding of multilayered hydrogel and a manufacturing method thereof. According to the present invention, a leg portion of a biological robot with various radiuses of curvature is designed by using three-dimensional (3D) structured multilayered hydrogel, such that the biological robot is variously utilized in drug delivery, tissue engineering, environmental engineering, and biomimetics fields. Moreover, a shrinkage force of a myotube cell differentiated by patterning fibronectin on the leg portion in a circular pattern by micro contact printing (μCP) method is 0.31±0.32 μN, but a shrinkage force of a myotube cell differentiated by patterning fibronectin on the leg portion in a linear pattern with a thickness of 100 μm is 1.12±0.30 μN, such that the shrinkage force of the myotube cell stronger that that patterned in the circular pattern by about 3.6 times, thus a 3D alignment technology for the myotube cell as well as a 2D alignment technology are introduced to provide a biological robot having excellent driving ability. According to the present invention, the multilayered hydrogel comprises: a plurality of temperature, pH, or light sensitive hydrogel layers; and a base hydrogel layer.
Year: 2018
Country: KR
Doc No: 20180130419