Biodegradable polyurethane having gradient elasticity modulus and tissue engineering fibrous scaffold prepared through same

23 Jul Biodegradable polyurethane having gradient elasticity modulus and tissue engineering fibrous scaffold prepared through same

Abstract

The invention discloses biodegradable polyurethane and preparation thereof, and an application of the biodegradable polyurethane in annulus fibrosus tissue engineering. The biodegradable polyurethane has the gradient elasticity modulus of 1.5-15 MPa, can be used for preparing a tissue engineering fibrous scaffold through a method of electrostatic spinning. Annulus fibrosus sourced stem cells can proliferate on the scaffold and differentiation of the stem cells are regulated and controlled by the elasticity modulus. An expression amount of a collagen I-type gene on the fibrous scaffold having a higher elasticity modulus is higher while expression amounts of a collagen II-type gene and a glycosaminoglycan gene on the fibrous scaffold having a lower elasticity modulus are higher. A cell tractive force detection result proves that a cell tractive force on the fibrous scaffold having the higher elasticity modulus is less and a cell tractive force on the fibrous scaffold having the lower elasticity modulus is greater, which is in conformity with a radial regional different of an actual annulus fibrosus, thereby providing possibility for researching the annulus fibrosus tissue engineering fibrous scaffold which can simulate regional difference of the annulus fibrosus.

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