23 Jul Biodegradable copolymer and thermosensitive material
Abstract
The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an encapped PEG or derivative thereof. The hydrophobic segment is a random polymer polymerized of lactone or cyclic C3-C6 molecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having phase transfer temperature of 25 to 50 DEG C, thereby being applied in biological activity factor transferring, tissue engineering, cell culture, and biological glue.
Year: 2009
Country: TW
Doc No: 200940597