23 Jul Biodegradable chitosan-based hydrogel and preparation method thereof
Abstract
The invention discloses biodegradable chitosan-based hydrogel and a preparation method thereof. The biodegradable chitosan-based hydrogel comprises, by weight, 65-100% of N-succinyl-chitosan and 0-35% of hyaluronic acid. The preparation method comprises the following steps of respectively dissolving the N-succinyl-chitosan and the hyaluronic acid in deionized water according to a mass ratio of N-succinyl-chitosan to deionized water of 1: 80-100 and a mass ratio of hyaluronic acid to deionized water of 0.5: 100, and carrying out full stirring at a room temperature for 1-5min to mix the two solutions so that the biodegradable chitosan-based hydrogel is formed. The preparation method has simple processes and mild reaction conditions, does not utilize any cross-linking agent and prevents toxic and side effects caused by the cross-linking agent in clinical use. The biodegradable chitosan-based hydrogel is stable for a long time, can be used in fields of drug carriers and biological tissue engineering and has a wide application prospect.
Year: 2014
Country: CN
Doc No: 104004232