23 Jul Biocompatible material and preparation method, double bone tissue repairing or replacing material and preparation method and application
Abstract
The invention relates to the field of bone tissue engineering, and discloses a biocompatible material and a preparation method, a double bone tissue repairing or replacing material and a preparation method and application. The preparation method of the biocompatible material comprises the step of mixing and stirring 15 to 32.5 parts by weight of a composite material of silk fibroin and hydroxyapatite, 0.5 to 2 parts by weight of sodium alginate, 2 to 8 parts by weight of silk fibroin and 65 to 75 parts by weight of water, wherein the composite material of silk fibroin and hydroxyapatite comprises a silk fibroin substrate, and a plurality of hydroxyapatite nanorods grown on the substrate, and the single nanorod is 200 to 500 nm in length and 10 to 30 nm in diameter. The prepared double bonetissue repairing or replacing material has a double structure, the external bone scaffold material has relatively high compressive strength, and internally has a porous structure favorable for the diffusion of nutrients and metabolites; meanwhile, the double bone tissue repairing or replacing material has the advantages of good biological activity, biocompatibility, non-toxicity and the like.
Year: 2019
Country: CN
Doc No: 109806445