23 Jul Biocompatible and temperature-sensitive nano composite hydrogel and preparation method thereof
Abstract
The invention relates to a biocompatible and temperature-sensitive nano composite hydrogel and a preparation method thereof. The hydrogel contains alkyl acrylamide M1 with temperature-sensitive property, inorganic nano-powder M2 and polyhydroxyalkanoate M3 with good biocompatibility, and the mass percentage of the three is 94-60: 1-20: 5-39. The preparation method comprises the steps that: the M1, the M2 and the M3 are subjected to in-situ free radical polymerization reaction in aqueous solution, and the nano composite hydrogel with biocompatibility and temperature-sensitive property is obtained after soaking and impurity removal. The method has simple and easily controlled preparation process, and can implement automatic desorption of cells by reducing the temperature; the biocompatibility and the temperature-sensitive property of the hydrogel can be adjusted by changing the density of a crosslinker, the dosage of the M3 and the component; and the method can be widely applied in the fields of tissue engineering and the like.
Year: 2010
Country: CN
Doc No: 101703805