23 Jul Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices
Abstract
Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: Rn .C00-(X)P-R’ Rn O-(X)p-R’ W. .O- (X)p-R’ OCN Rn Rn NH-(Y)P-R’ ‘COO-(X)P-R’ V^. ^0-(Y)P-RI OCN H 2 N or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from -CH 2 COO- (glycolic acid moiety), -CH(CH 3 )COO- (lactic acid moiety), -CH 2 CH 2 OCH 2 COO- (dioxanone), -CH 2 CH 2 CH2CH 2 CH 2 COO- (caprolactone moiety), -(CH 2 )yCOO- where y is one of the numbers 2,3,4 or 6- 24 inclusive, and -(CH 2 CH 2 O)Z CH 2 COO- where z’ is an integer between 2 and 24, inclusive; each Y represents a member independently selected from -COCH2O- (glycolic ester moiety), -COCH(CH 3 )O- (lactic ester moiety), -COCH 2 OCH 2 CH 2 O- (dioxanone ester), -COCH 2 CH 2 CH 2 CH 2 CH 2 O- (caprolactone ester), -CO(CH 2 )mO- where m is an integer between 2, 3, 4 or 6 – 24 inclusive, -COCH 2 O(CH 2 CH 2 O)n- where n is an integer between 2 and 24, inclusive; R’ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid and -NO 2 , which is attached directly to an aromatic ring or attached through an aliphatic chain. Absorbable poly- mers prepared from these compounds are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention and other implantable medical devices.
Year: 2011
Country: EP
Doc No: 2298235