23 Jul Attapulgite (ATT)-doped PLGA nano-fiber felt, as well as preparation method and application thereof
Abstract
The invention relates to an attapulgite (ATT)-doped PLGA nano-fiber felt, as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving PLGA in a mixed solvent to obtain a PLGA electrospinning solution; uniformly dispersing ATT in the PLGA electrospinning solution while stirring to obtain a PLGA/ATT electrospinning solution; and electrospinning by adopting the PLGA/ATT electrospinning solution for preparation. Nano-fibers promote human mesenchymal stem cells (hMSC) to be differentiated into bone cells. According to the preparation method provided by the invention, the process is simple, the product is easy to obtain, and the cost of used PLGA and ATT is relatively low; the prepared ATT-doped PLGA nano-fibers have good mechanical properties, blood compatibility and biocompatibility, and have broad application prospects in the fields of pharmaceutical carriers, tissue engineering scaffold materials and the like.
Year: 2015
Country: CN
Doc No: 104258464